Allergies!!?

An amazing webpage debriefing allergies through the lens of developmental psychology.

By: Jennifer Wen

Lifespan Development 251-Professor Emily Hazlett

According to the CDC, one quarter (25.7%) of adults have a seasonal allergy…. Beware as pollen season is comming soon.

So what are Allergies?

Allergies are your body’s reaction to normally harmless substances such as pollen, nuts, and more. Reactions range from mild to life-threatening, such as in the case of anaphylaxis.

Essentially, your immune system ‘glitches’ and overreacts because it struggles to determine whether to initiate a Type 1 or Type 2 immune response to allergens- as they are technically harmless. system is oversensitized and releases chemicals- such as histamine- which gives you your runny nose, watery eyes, etc.

Type 1 Immune Response

Function: targets and kills pathogens directly

Target: intracellular pathogens, such as viruses and bacteria

Type 2 Immune Response

Function: expels foreign substances or pathogens

Target: primarily parasites and other external threats

Thats annoying. Do we know why we’ve evolved to have allergies?

Short answer: No. But……. We can analyze this phenomenon through the lens of developmental psychology or more specifically: Nature vs. Nurture.

Nature vs. Nurture. That sounds familiar, what was that again?

Nature vs. Nurture started out as a debate against whether Nature or Nurture factors play a more important role in development. The general consensus now is that both factors play important interacting roles. We will explore this further with allergies. 

Nature

Refers to the genetic material/ innate traits that one naturally has.

Nurture

Refers to environmental factors that could impact one’s development.

Here is where we diverge:

Explore the timeline of how how our understanding of allergies has evolved.
Explore mainstream hypotheses related to allergies.

Let’s explore how our understanding of allergies has evolved over time.

1991

Toxin Hypothesis

In 1991 Margie Profet proposed the
Toxin Hypothesis- the idea that allergies serve as an evolutionary defense mechanism, acting as a last line of defense against natural toxins such as venom and toxic plant compounds.

This hypothesis remains debated, however, it marked the beginning of considering allergies from an evolutionary perspective.

Margie Profet- she was highly controversial for her other research hypotheses, which may have overshadowed her proposal of the Toxin Hypothesis.

1999

Ooo Nature and Nurture?

Emerging research started demonstrating that
allergies are a possible result of complex interactions between unknown genetic and environmental factors.

1999

Environmental Factors? Maternal-Fetal Interations

Early life development is especially important for infants to gain immunity- particularly through immune interactions between the mother and child.

Maternal- Fetal Interactions can be facilitated through breastfeeding as the maternal antibodies are transferred to the infant through breastmilk.

This is an example of nurture influences.

Antibodies

Protein markers that help the immune system recognize pathogens.

Present

Strong genetic basis for Allergies

With advancements in technology, our understanding of the role of genetics in allergies has improved.

We now know that genetics can influence the expression of specific proteins in the body which trigger allergic inflammatory responses. A strong genetic basis has been established, allowing us to describe allergies as phenotypes.

Phenotype

Observable traits expressed as a result of interactions between genetic and environmental factors.


Toxin Hypothesis

Learn more about the logic behind the Toxin Hypothesis.


Hygiene Hypothesis-Supported

Learn more about evidence supporting the hygiene hypothesis.


Hygiene Hypothesis-Challenged

Learn more about evidence challenging the hygiene hypothesis.

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